A separate evidence base. Not an extrapolation.
Pediatric sepsis physiology, dosing parameters, and reported outcomes differ materially from adult cohorts. PLEXSO indexes only peer-reviewed pediatric TPE data—organized by age range, sepsis subtype, and clinical outcome.
Each entry in the pediatric bibliography is tagged by patient age band (neonatal, infant, school-age, adolescent), sepsis subtype, and primary reported outcome. Case series, controlled cohort data, and protocol reports are tracked separately and labeled accordingly.
Curated for the PICU clinician
As new papers clear peer review, PLEXSO members receive indexed additions before general release. The corpus is small but growing—and it is tracked in full.
Selected pediatric TPE literature
TPE in pediatric septic shock: a retrospective cohort
Plasma exchange volume and cytokine clearance in PICU sepsis
Age range: 1 month–14 years. Subtype: gram-negative septic shock. Outcomes: vasopressor reduction at 48 h, 28-day mortality. Retrospective single-center cohort, n=34.
Age range: 6 months–16 years. Subtype: polymicrobial sepsis. Outcomes: IL-6 and TNF-α kinetics, organ dysfunction scores. Prospective observational, n=22.
Neonatal sepsis and TPE: case series and protocol review
Multi-organ dysfunction and adjunct TPE in school-age sepsis
Age range: 0–28 days. Subtype: early-onset neonatal sepsis. Outcomes: coagulation normalization, NICU length of stay. Case series, n=9.
Age range: 5–12 years. Subtype: community-acquired sepsis with MODS. Outcomes: PELOD-2 score trajectory, ventilator-free days. Controlled cohort, n=41.
How papers enter the index
Full annotations available to members
Annotated entries include protocol summaries, reviewer commentary, and cross-references to related adult literature where clinically relevant.
Entries are reviewed by at least two PLEXSO members with PICU or transfusion medicine credentials. Papers must report primary outcome data specific to a pediatric population; adult data with pediatric subgroup footnotes do not qualify.
Case series below n=5 are held pending corroborating data. Preprints are tracked but not indexed until peer-review clears. Every entry is re-evaluated annually against updated clinical guidelines.