Clinical perspective between publication cycles
Protocol updates, data discussions, and field observations authored by practicing intensivists and transfusion specialists—not editors.
Preliminary. Practice-informing. Clearly labeled.
Protocol Updates · Emerging Data · Pediatric TPE · Adult ICU · Case Discussion · Dosing & Access
Posts here are clinical commentary—not peer-reviewed publications. Each entry is labeled accordingly. For curated peer-reviewed literature, see the Research section.
Revisiting replacement fluid ratios in refractory septic shock
What the TIGRIS sub-analysis means for dosing decisions
Access site selection in pediatric septic shock: a practical note
A PLEXSO member unpacks the secondary endpoints from the TIGRIS sub-analysis and their practical implications for session volume and timing in adult sepsis.
Recent unit-level data prompted a re-examination of FFP-to-albumin ratios during TPE runs in vasopressor-dependent adults. A protocol adjustment and its rationale.
Weight-based access constraints in small children demand a different decision framework. One PICU intensivist outlines the criteria guiding catheter selection at their center.
Dr. M. Okonkwo · Adult Critical Care · Commentary
Dr. S. Ramirez · Transfusion Medicine · Commentary
Dr. L. Nguyen · Pediatric Critical Care · Commentary
When to initiate TPE in gram-negative bacteremia: decision points
Standardizing discontinuation criteria across a multi-site ICU network
Plasma volume calculation methods: where units diverge
Formula choice for estimated plasma volume affects exchange volume targets. A review of Nadler versus weight-based approaches and the clinical rationale behind each.
A structured case discussion examining trigger criteria, timing of initiation, and the evidence gaps that still require institutional judgment in gram-negative bacteremia.
Stopping rules for TPE vary widely between institutions. This post outlines the criteria one network converged on after a structured review of available outcome data.
Dr. A. Petrov · Infectious Disease · Commentary
Dr. C. Osei · Adult Critical Care · Commentary
Dr. T. Balogun · Transfusion Medicine · Commentary
Members author this record. Qualified clinicians write here.
Membership provides submission access, peer review of commentary before publication, and full access to the curated research archive.