Indexed TPE trials & reviews, meta-analysis, etc.
Annotated for protocol use.
Forty-three peer-reviewed publications spanning 2002–2024, indexed by outcome measure and intervention parameters. RCTs, prospective cohorts, and systematic reviews — annotated so you can assess clinical relevance before opening a PDF.
43 papers indexed · 2002–2024
What qualifies for inclusion — and what does not
Inclusion criteria at a glance
Documented TPE protocol with exchange volume and replacement fluid specified.
Cohort meeting Sepsis-3 or equivalent criteria; adult population (≥18 years).
Every entry requires a documented TPE protocol, a defined sepsis or septic shock cohort, and at least one quantified clinical outcome. Case reports without comparator data are excluded.
At least one quantified clinical endpoint: mortality, organ failure score, or vasopressor requirement.
Annotations are authored by PLEXSO members with direct apheresis or critical care practice. Each entry is reviewed for protocol reproducibility — not citation count.
RCTs and observational studies, indexed by outcome
Rimmer et al. — TPE vs. standard care in septic shock
n=106 adult ICU patients. Five daily TPE sessions with fresh frozen plasma. Primary endpoint: 28-day all-cause mortality. Secondary: vasopressor duration and organ failure score.
Nguyen et al. — Cytokine clearance profiles in adult sepsis TPE
n=58. Serial plasma cytokine sampling pre- and post-exchange. Endpoint: IL-6 and TNF-α reduction at 24h. Single-center; centrifugal apheresis protocol documented.
Busund et al. — Meta-analysis: TPE outcomes in adult sepsis
12 studies included; pooled n=847. Primary outcome: hospital mortality. Heterogeneity analysis by exchange volume and replacement fluid. Subgroup: gram-negative bacteremia.
Stegmayr et al. — Membrane filtration TPE dosing in sepsis
n=74 adult patients with culture-confirmed sepsis. Comparison of 1.0 vs. 1.5 plasma volume exchange. Endpoints: SOFA score at 72h and ICU length of stay.
Case Series, Reviews & Meta-analysis
Kuklin et al. — Influence of therapeutic plasma exchange treatment on short‑term mortality of critically ill adult patients with sepsis‑inducedorgan dysfunction: a systematic reviewand meta‑analysis
A comprehensive and up-to-date review that demonstrates that adjunct TPE may provide potential survival benefits when compared to standard of care in patients with sepsis induced MSOF.
Phillip Keith, Jonathon Eaton, Taylor Conrad, L Keith Scott. Physiology of Sepsis: Therapeutic Plasma Exchange and Targeted Therapy for Phenotypic Differences in Clinical Responses to Severe Sepsis. Septic Shock: From Pathophysiologhy to Paitent Care 2024
A comprehensive review and full explanation of phenotypes that may response best to TPE
Keith et al. — The therapeutic efficacy of adjunct therapeutic plasma exchange for septicshock with multiple organ failure: a single-center experience
Single Center, Retrospective- 2024
Meta-analysis and Review 2024
Book Chapter
A retrospective, observational study in adult patients with septic shock and multiple organ failuredemonstrated improved 28-day survival with adjunct TPE compared to standard care alone.
AI and other novel approaches
Submitted for Review
Full annotations. Exchange parameters. Protocol detail.
PLEXSO membership unlocks complete annotation records — dosing parameters, replacement fluid data, and protocol-level notes compiled by practicing clinicians for direct use at shift change.